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Exact(7)
The most enriched protein domain in both the 21 positives we report (Table 1) and the 513 target genes are the CUB (or CUB-like) domain (C1r/C1s, Uegf, Bmp1) [27].
Of these, 11 belong to the most enriched protein families in Pezizomycotina [ 39].
4) Strikingly, the most enriched protein in mitotic CCS is NSF.
The three most enriched protein classes were kinases, transcription factors and phophatases (Table 1).
To analyse the landscape of the most enriched protein classes with known and predicted lynchpins, we used the DAVID database (41).
3) Can the authors test whether hypo-osmotic conditions (relieving the presumed increase in mitotic cell surface tension) 're-starts' CME? 4) Strikingly, the most enriched protein in mitotic CCS is NSF.
Similar(53)
Among the four types of network motifs, the crosstalk was found to have the most enriched protein-protein interactions in their downstream regulatory targets.
The most enriched proteins released were the nucleosomal histones, which have previously been identified as damage-associated molecular pattern proteins (DAMPs) that can initiate sterile inflammatory responses.
Among the 20% most enriched proteins, chromosomal proteins outnumbered nonchromosomal proteins by 3 to 1. Conversely, among the 20% least enriched proteins, background proteins outnumbered chromosomal proteins 6 to 1.
Several of the most enriched proteins (plectin, glial fibrillar acidic protein, vimentin, Hsp 27, and ubiquitin) are known to form complex astrocytic inclusions, so-called Rosenthal fibers, in the neurodegenerative disorder Alexander disease.
Filtering differential normalized spectral abundance factor (NSAF) (Zybailov et al., 2006) values from both control and Flag-A51R immunoprecipitates identified the four most-enriched proteins in Flag-A51R treatments.
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