Sentence examples for most enriched motif from inspiring English sources

Consistent with previous reports demonstrating the role of BRG1 in OCT4-dependent transcription12, the motif for the master pluripotency regulators OCT4/SOX2/TCF/NANOG was the most enriched motif for esBAF complex binding, followed by motifs for the high-mobility group domain-containing Sox family members.

The TRASNFAC E2F1 motif M00918 was identified as the most enriched motif in E2F1 targets, and the TRASNFAC E2F1 motif M00428 was identified as the most enriched motif in JUND targets.

Note that selection of the single most enriched motif for estimating recall is an exceedingly strict criterion.

For each TF, the single most enriched motif was compared to the TRANSFAC reported motifs for that TF.

The TRANSFAC E2F1 DNA-binding motif M00918 was the most enriched motif with sites in promoters of predicted E2F1 targets.

We noted that the most enriched motif among these proteins (present in 17 proteins) was the actin-binding calponin homology (CH) domain.

Motif analysis revealed that the most enriched motifs within the TRIM24 binding sites were the forkhead motif followed by ARE (androgen response elements) (Supplementary Data 1).

However, both JUN and E2F-1 M00428 (M00428 and M000172) were among the top 5 motifs for all JUND test sets, and they were significantly enriched in the JUND combined-conservation set, where the reported AP1 and E2F1 motifs were the most enriched motifs.

Among the significantly overrepresented motifs of size 4, 5 and 6, the bifan and the feedforward motifs were the top most enriched motifs detected (Additional file 2).

SeAMotE was able to correctly reproduce the most enriched motifs using training and testing sets, thus confirming the robustness of our approach (Additional file 3: Table S2).

Among others, we detected GC sequences and the Sp1 motif, as expected for a TIEG family member, but in addition, one of the most enriched motifs comprised GAGA-binding sequences (Fig 2A).