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Exact(5)
It also does not address the most appropriate duration of use and is likely to be simplistic and overly optimistic.
Many interventional ICU trials have used different durations of follow up with which to assess mortality but the most appropriate duration of follow up is uncertain [ 3- 7].
This is an important issue in determining the most appropriate duration of use, which could be longer than the 10 years used in our base case scenario.
Length of stay was analysed to ascertain the most appropriate duration qualifying criterion to apply when determining hospital-acquired pressure ulcers in children.
I also think it is premature to use these trials to make conclusions about the most appropriate duration of adjuvant treatment with an aromatase inhibitor, as duration of AI treatment ab initio is clearly different from switching to an AI after several years of tamoxifen treatment.
Similar(55)
The most-appropriate duration of follow-up for clinical outcomes may differ from those outcomes needed to estimate the long-term cost-effectiveness of an intervention, even if the observed cost-effectiveness ratio is trending towards that of the long-term ICER [ 34].
Lastly, the most appropriate frequencies, durations, and amplitudes of vibration necessary for a beneficial response are unknown, and the type of vibratory signal (e.g., sinusoidal) is often not reported.
Treatment with adjuvant interferon alfa‐2b (IFN‐ α‐2b) is associated with improved relapse‐free and overall survivals (OS), but the most appropriate dose and duration of treatment are unknown.
There are; however, currently no clinical guidelines regarding the most appropriate type, intensity and duration of activity to prevent bone loss.
The issue, from a clinical perspective, is that there are no guidelines available regarding the most appropriate type, intensity and duration of physical activity to best provide protection against bone loss and/or fracture.
There is a clear need for further research in order to identify the most appropriate interventions for increasing breastfeeding duration.
Related(20)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com