Here we show that the most relevant difference is the duration of CK2 inhibition, since in CX-4945 treated cells CK2 activity is rapidly restored to basal levels after the removal of the inhibitor, while in TDB-treated cells the inhibition lasts for several days.
Indeed, careful examination of these trials shows that they share the following common features: inclusion of the most severe patients (ARDS only, excluding acute lung injury (ALI) non-ARDS patients), and control for the most relevant confounders - that is, proning duration (usually >17 hours/day) and use of lung-protective ventilation [ 10, 16, 17].
The most relevant conditions are cell line, dose, and treatment duration.
The most relevant one is probably the rather short, 1-month, duration of the treatment periods in the randomized phase.
Our results suggest that headache intensity and duration of headache history are the most relevant factors for migraine patients, whereas headache frequency is the most important index of severity in TTH patients.
The most relevant aspects perceived by operators basically refer to its duration, while the general impact will be concerned with the magnitude of logistics flow among the different areas.
The absence of menarche before admission, a higher premorbid BMI, discharge below target weight, and a longer duration of hospital treatment were the most relevant prognostic factors for continued amenorrhea.
Intensity, duration, and extent would appear to be the most relevant variables here.
We were able to show that the duration of the rub-in procedure is not the most relevant parameter to ensure a high quality of the hygienic hand disinfection procedure.
From studies that reported risks over two or more different durations of follow-up (from a fixed timepoint of baseline RNA or CD4 measurement) [30], [31], we included the estimate for the shortest follow-up duration, as short-term prognostic indications are likely to be most relevant in patient management.
