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However, two major issues arise: 1) such dichotomized outcomes are inefficient in terms of using the information available and can seriously reduce the power of the study; and 2) the results of clinical trials depend considerably on the response cutoff chosen, yet in many disease areas there is no consensus as to what is the most appropriate cutoff.
The most appropriate cutoff was 15%max for both ventilation and perfusion images.
To automatically delineate functional volumes with 68Ga-V/Q PET/CT, the most appropriate cutoff was 15%max for both ventilation and perfusion images.
We therefore selected 0.8 as the most appropriate cutoff value.
To determine the most appropriate cutoff, all of the three parameters were divided into quartiles.
Application of the GR assay in a clinical setting will help provide additional guidance on the most appropriate cutoff thresholds.
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Deng et al. determined the most appropriate cutoffs of metastatic lymph nodes to be 0, 1–4, 5 8, and ≥9 in 308 gastric cancer cases with curative resection classified by the 6th edition system.
In order to derive the most appropriate sFas cutoff value for use in diagnosing UC, a receiver operating characteristic (ROC) curve was constructed.
Of note, the composition of the control group influences the figures for specificity and sensitivity of VEGF in the diagnosis of LM: if the control group was restricted to patients with presumed infectious disease as the most appropriate controls, specificity at a cutoff level of 250 pg ml−1 would be reduced from 98.3 to 94.5%.
Moreover, we feel it is most appropriate to use 26.55 as the cutoff as this is the empirically validated cutoff value.
Further studies are warranted to investigate which cutoffs are the most appropriate for defining high versus low TATI expression.
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