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Mutant cells differentiate normally and appear morphologically normal, with small OSs and extended synaptic processes, until ∼4 d.p.f.
Both temporomandibular joint complexes were morphologically normal with slightly underdeveloped condylar processes and a noted absence of expected movement of the condyles or discs in the open mouth position.
Transduced cells appeared morphologically normal with no reduction in culture lifespan.
Mutant adults appeared to be morphologically normal with the exception of defects in abdominal segmentation.
yap1 −/− homozygous mutants embryos were morphologically normal with smaller and at times rounder pLLP, a phenotype identical to that of the yap1 morphants.
Electron microscopy of the proximal nerve revealed numerous naked axons that appeared morphologically normal, with interspersed astrocytic processes (Fig 2A and Supporting Information Fig S1A).
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Our finding is consistent with the 43.4% morphologically normal sperm with acceptable fertility [ 6], but lower than the value for fertile stallions (75.5%) reported by Pesch et al. [ 7].
While the green sectors of the leaves have morphologically normal plastids with the same levels of chlorophyll and carotenoids compared with wild-type leaves, the yellow (or white) sectors contain chloroplasts with defective thylakoid stacking and less photosynthetic pigments (Li et al. 2010; Han et al. 2012; Carol et al. 1999).
In summary, 69 genes were significantly differentially expressed between rx3 -/- mutants and the morphologically normal siblings, with 23 genes significantly down-regulated and 46 significantly up-regulated with ≥1.5 fold change.
Previous studies have shown that Oct4 null embryos initially establish morphologically normal blastocysts, with appropriate TE-restricted expression of Cdx2 in early blastocysts [47], [48].
Likewise, others have evidenced that subpopulations of sperm with higher MMP (isolated using either 3,3'-dihexyloxacarbocyanine iodide or chloromethyl-x-rosamine) also have more motile and morphologically normal gametes, with a higher capacity to respond to induced acrosome reaction [43].
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