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Indeed, the mitochondrial morphological abnormalities associated with Parkin deficiency highlight a role for Parkin in mitochondrial fusion and fission events (14).
However, additional studies are still warranted in order to assess whether these structural abnormalities are specific to PTSD or represent non-specific morphological abnormalities associated to trauma exposure.
Previous neuroimaging studies have revealed widespread morphological abnormalities associated with AVHs, such as gray matter loss in the frontal [ 4, 5], insular [ 6], and anterior/posterior cingulate [ 7, 8] cortices.
It is not unusual to encounter a number of abnormal sperm forms in any ejaculate; only when present in large numbers are morphological abnormalities associated with impaired fertility in the stallion [ 21].
Recent work has strongly drawn the attention to the mitochondrial fragmentation and other morphological abnormalities associated with PINK1 deficiency (Clark et al, 2006; Deng et al, 2008; Exner et al, 2007; Park et al, 2006; Poole et al, 2008; Yang et al, 2006).
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Here, in this work, we have characterized the morphological and subcellular abnormalities associated with dystrophic neurites around plaques in the hippocampus of our PS1/APP model at 4 6 months of age.
The morphological abnormalities relate to cell structure, number of cells, and cytological appearance of the epithelium.
However, several neurodegenerative disorders manifest aberrant mitochondrial dynamics, resulting in morphological abnormalities often associated with deficits in mitochondrial mobility and cell bioenergetics.
Early studies evaluating the Technicon H-1E haematology analyser described cytogram abnormalities associated with specific morphological white blood cell changes [ 14, 15].
Because layer II/III pyramidal cells are intercortical neurons, the loss of dendritic spine number and morphological abnormalities can be associated with disrupted communications between higher cortical areas, thus providing a possible explanation for the behavioral alterations.
Furthermore, in seven of the 50 lines (14%), histopathology revealed significant morphological abnormalities that were neither associated with nor predicted by clinical changes detected in the standard primary phenotyping screen.
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