It is interesting that inhibition of autophagy by Atg7 siRNA also seemed to alleviate some of the mitochondrial morphological and functional abnormalities caused by MPP+.
Minor adrenal morphological abnormalities have been observed in patients with lung cancer.
Surgical techniques to address the underlying morphological abnormalities have evolved with the concept of FAI.
It consists in speech abnormalities caused by neuromuscular disorders.
BMPs have also been associated with normal gastrointestinal tract development in vertebrates, and alterations in their expression caused morphological abnormalities in the intestinal tissues ([ 56, 57]).
Microinjection of either Hdac1ATG1 or Hdac1SPL1 morpholinos into embryos caused morphological abnormalities that closely resembled the hdac1 mutant phenotype (data not shown), and which were first detectable at ~24 hpf.
We found that constitutive expression of TGMV- TrAP in Arabidopsis thaliana caused morphological abnormalities that mimic loss-of-function mutants of numerous TGS components including lhp1 (like-heterochromatin1) and clf.
Overexpression of sbh1+ also diminishes protein secretion of a model protein, increases sensitivity to cell-wall stress, and causes morphological abnormalities.
We have generated a zebrafish knockdown model in which we demonstrate that a lack of mbnl2 function causes morphological abnormalities at the eye, heart, brain and muscle levels, supporting an essential role for mbnl2 during embryonic development.
