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DBI is a particularly promising candidate for the regulatory pathway responsible for the brain and morphological defects associated with ZS.
Defects in membrane potential, respiratory distress and inefficient transport can all secondarily contribute to the morphological defects associated with mutant Htt expression.
Embryos that exhibited gross morphological defects associated with RNA toxicity or morpholino toxicity or other idiopathic growth defects were excluded from the analysis.
As not all hemisegments in homozygous mutant embryos exhibit this latter phenotype, we assessed whether there is any correlation between the de-repression of a specific gene and the morphological defects associated with mutations in jumu or CHES-1-like.
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We did not recognize any morphological defect associated with knockout of these genes (Fig. 3A C).
Although the most critical birth defect associated with alcohol consumption is fetal alcohol syndrome (FAS) [ 2], many children who were prenatally exposed to alcohol do not present the morphological brain changes characteristically seen in FAS, yet they may still exhibit many of the mental dysfunctions induced by ethanol [ 3].
The results showed good crystalline behaviors and morphologies without any identifiable morphological defects.
Gross morphological defects were observed in the mitochondria and these aberrations were associated with metabolic imbalances and a diminished capacity for respiration.
In Arabidopsis, morphological defects in hmg[ 56], cyp51[ 3], and cas1[ 2] mutants were shown to be associated with cell wall gaps and aberrant cell wall thickenings.
No evidence of outer membrane vesiculation, which has been associated with alterations in σE activity [33], [34], or other gross morphological defects were observed in the TEM or SEM images.
We have described the wing phenotype associated with the pkn dln allele as a composite of several morphological defects.
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