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Exact(11)
A P value of <0.05 was considered statistically significant; for multiple combinations (n = 10) of pairwise comparisons, a more stringent P value of <0.005 was used.
Owing to multiple outcomes, we regarded a more stringent P value of ≤0.01 as statistically significant for the main analyses.
As a practical matter, the walk can be stopped at more stringent p values without changing the main conclusions.
A more stringent p value of <0.01 was considered significant to minimise type I error owing to multiple comparisons.
With a more stringent p value of ≤ 0.01, 14 genes were differentially regulated by ≥ 1.3-fold with 7 genes up-regulated and 7 down-regulated.
We could have set a more stringent p value at 0.001 for an overall α level of 0.05 the Bonferroni method.
Similar(49)
Figure 3 shows that when more stringent p-value thresholds are used to define GWAS hits, the Bayes Factors increase.
Subsequent analysis of the identified Hox-clusters using more stringent P-value cut-offs improved the resolution for some of the clusters.
Allowing ambiguities obviously increases the size of the search space and very relaxed ambiguous searches may need to use a more stringent p-value accordingly.
In order to avoid missing biological relationships because of the arbitrary nature of the cut-offs used to generate gene lists, we compiled additional lists of up and down-regulated genes for each of the EBNA3 knockouts, using more stringent p-value criteria (<0.0001) for smaller fold-changes (>1.3).
In this case, a more stringent P-value is to be used in exchange for lower sensitivity rates.
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