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Also, valgus alignment increases the risk of progression of lateral disease, and an increasing valgus angle is associated with more severe progression of lateral disease [2, 20, 21].
Male RTT patients have also been described; they usually suffer a more severe progression.
A longer CAG expansion may lead to an earlier onset [2] and a more severe progression of clinical symptoms.
[17], [18], [19] We speculated that genetic predisposition to different patterns of glycosylation in the ABH pathway would lead to early chronic lung infection in CF, and therefore, more severe progression of disease.
These mice displayed a neurodegenerative phenotype similar to that observed in hA30Pα-syn mice, but with more severe progression: by 12 months of age, 50% of the hA53Tα-syn mice were affected [51], whereas at this age, none of the hA30Pα-syn mice in our study presented features of disease.
They exhibited more severe progression on follow-up.
Similar(50)
Our results indicate that CD4+ T cells are not required for disease progression once arthritis is established, because the mice treated with only GK1.5 showed comparable disease progression or a trend towards more severe disease progression compared with the control groups.
Although diabetic patients had more severe plaque progression than non-diabetic counterparts, no relations existed between plaque progression and genotypes (all p > 0.05) (Table 4).
Enhanced motility and/or invasiveness of CT45-positive cells could contribute to the more severe disease progression that is correlated to CT45-positivity in several malignancies.
Although diabetic patients had more severe plaque progression than non-diabetic counterparts, risk genotype of rs1333049 was not an independent determinant of plaque progression in diabetes.
Children and adolescents with newly diagnosed type 1 diabetes are more likely to present with several autoantibodies than adults, probably reflecting a stronger autoimmune state and a more severe disease progression.
Related(20)
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