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We used Trichrome-Masson-Goldner staining to quantify our results and found that immunized rats developed more severe fibrosis than control rats (Figure 5 A, B).
Irradiation induced more severe fibrosis than bleomycin.
In hepatitis C, steatosis is associated with more severe fibrosis and rapid disease progression [ 6, 7].
However, more severe fibrosis responses were observed in the high-dose group.
They found that the cluster with more severe fibrosis plus inflammation and arterial lesions had the worst prognosis.
Similar to H & E staining, trichrome staining revealed more severe fibrosis in L3 SMGs of Atg5 WT mice than the corresponding SMGs of Atg5 KO mice.
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Notably, Col-GFP mice receiving a second course of CCl4, after complete recovery from the first, developed more-severe fibrosis than previously untreated littermate controls receiving CCl4 for the first time.
In a murine lung model of bleomycin-induced fibrosis, Thy-1 deficient mice develop more severe lung fibrosis in comparison to wildtype littermates [19].
Conversely, supplementation of young mdx mice with L-arginine promoted a more severe muscle fibrosis than mdx mice treated with D-arginine confirming a role for arginase in fibrosis and disease pathogenesis [ 54].
In addition to more severe liver fibrosis and tumorigenesis after DEN plus CCl4 treatment, hepatocyte-specific gankyrin-overexpressing mice (gankyrinhep) exhibited malignant transformation from liver fibrosis to tumors even under single CCl4 administration, whereas wild-type mice merely experienced fibrosis.
Likewise, Thy-1 deficient mice display more severe lung fibrosis in response to an inflammatory injury than wildtype littermates.
More suggestions(15)
more severe disease
more robust fibrosis
more severe type
more rapid fibrosis
more severe injury
more severe penalty
more pronounced fibrosis
more severe lesion
more mature fibrosis
more cardiac fibrosis
more hypertrophy fibrosis
more severe punishment
more severe comorbidity
more severe morbidity
more compact fibrosis
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