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The larger Loxosceles laeta of South America causes a more severe lesion.
One of the problems encountered when facing a CIN1 is to misdiagnose a more severe lesion firstly because of the intra- and interobserver variability and secondly because the colposcopy-directed biopsy is not mandatorily representative of the more severe lesion.
Data from trials studying the contribution of HPV testing in case of CIN1 show that its sensitivity is similar to repeat cytology with less referral to colposcopy to detect CIN2 or more severe lesion.
Concerning the natural history of CIN1, the recent studies, which included more than 1200 women and more than 700 for two of them, confirm that the rate of progression of a CIN1 to a CIN3 or more severe lesion is less than 9% in the two years following the initial diagnosis (LE2).
A CIN1 is associated with a risk of evolution to a CIN2 or more severe lesion that is not markedly more important than the risk associated with a LSIL/ASC-US pap smear while the colposcopy is normal or the biopsy is negative (between 8 and 13% whatever the results of the initial colposcopy) (LE 2/3).
Women with a cytologic diagnosis of ASC-US or more severe lesion were scored as Pap smear positive.
Similar(44)
The more severe lesions correspond to our Fioretto C2 cases, stratified by severity of diabetic glomerular changes.
Significant early acne can be a predictor of more severe lesions.
The incidence of more severe lesions such as necrosis and cartilage thickening was less common.
Those without the surface molecule developed much more severe lesions, and higher numbers of them.
Rutgeerts et al. [29] have shown that patients with absent or very mild lesions on endoscopy following surgery have a very good prognosis, whereas patients with more severe lesions on endoscopy develop early clinical recurrence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com