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For a more physiological response, the in vitro tests should match biomaterials with cell populations typical of the implant site.
In acute testing, as compared with XL and DDD, CLS provides a more physiological response during the performance of activities of daily living for subjects with ≥80% pacing.
Co-culturing cancer cells with fibroblasts in 3D heterotypic microtissues can mimic breast cancer heterogeneity, allowing a more physiological response to screening [ 13– 15].
They also showed an enhanced sensitivity toward mitogens and a more physiological response to the growth-promoting effects of several carcinogens (Gebhardt and Fischer, 1995; Klein and Gebhardt, 1997).
In order to compare the cognate hybridoma data with a more physiological response in vivo, the HLA-DR4trg mice were immunized in the footpad with the WT peptide and, seven days later, the popliteal lymph node cells were assayed for their proliferative response and cytokine production when stimulated with the WT peptide or single site substituted APLs (compounds 12 to 20).
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Those results indicate a more positive physiological response to stress by children who were more active, the researchers said in a study that was published this week in The Journal of Clinical Endocrinology and Metabolism.
Experimental evidence has suggested that this L-type calcium antagonist causes CSI to revert to a more physiological haemodynamic response to CSD and, thus, may protect the brain (Dreier et al., 1998; Windmüller et al., 2005).
The canonical RGD motif from the 10th domain interacts primarily with αv integrins and induces mesenchymal-like behavior in epithelial cells, while inclusion of the 9th domain PHSRN synergy site fosters interactions through integrin α5β1 and a more physiological phenotypic response.
Not all experienced such benefits, and Feldman is currently waiting to see whether she will receive funding from ALSA to conduct larger trials, using specialised imaging scans to try to pinpoint why certain patients have a more positive physiological response to stem cells than others.
In this case, the generation of new sensory neurons during pregnancy may be related to a more fundamental physiological response, such as an increase in sensitivity or establishment of new connections with AOB targets.
Finally, proteins such as the transcription factor HIF-1α and HGF, which can simultaneously stimulate the expression of multiple growth factors involved in post-ischemic vascular response and tissue recovery, have been reported to achieve more physiological angiogenic responses than individual growth factors alone (Taniyama et al., 2001; Patel et al., 2005; Pyun et al., 2010; Li et al., 2011).
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