Exact(5)
Through time, more and more mutations with frequency-dependent influence on fitness are captured in the population.
Did it involve the rapid fixation of one or more mutations with effects of a magnitude similar to the p.D273RfsX13 MSTN mutation?
While predictive power increases when more mutations with smaller effects contribute, predictability is retained down to relatively small number of mutations contributing to fitness differentials.
This implies that including more mutations with lower read depth will increase N and lead to greater precision in the estimate of π despite the lower precision of each individual location.
This occurs as one duplicate is more constrained to retain "old" interactions, while the other duplicate is less constrained and thus accumulates more mutations with the likely outcome to become nonfunctional by loosing all its duplication-derived interactions, unless some of them are eventually retained by selection.
Similar(3)
Abbreviations: PI, protease inhibitor; NRTI, nucleoside reverse transcriptase inhibitor; NNRTI, non-nucleoside reverse transcriptase inhibitor; TAMs, thymidine analogue associated mutations Of note, 9/15 (60.0%) of these patients carried HIV-1 strains with two or more mutations associated with transmitted drug resistance.
The additional observation that various phenotypes must be acquired suggests multiple mutations with no clonal expansion or a mutator mutation (a mutation that generates more mutations) coupled with clonal expansion [ 41].
Samples from 1654 (11.3%, 95% confidence interval 10.8%too 11.9%) patients had one or more mutations associated with transmitted HIV-1 drug resistance.
Related(19)
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