Sentence examples for more hypoxic environment from inspiring English sources

This dichotomy in results may be explained by the role of vessel normalization in the response of tumors to anti-angiogenic therapy, where anti-angiogenic therapies may initially improve both the structure and the function of tumor vessels, but more sustained or potent anti-angiogenic treatments will produce an anti-vascular response, producing a more hypoxic environment.

TMEM45A expression was not higher in the basal layer despite the fact that the basal layer has been shown to be in a more hypoxic environment [ 38, 39].

Further, the tumor center, which can have fibrosis, may represent a more hypoxic environment what might contribute to EMT transformation [ 25].

The tPO2 levels significantly correlated with macroscopic synovitis (r=−0.421, p=0.02) (figure 1B) and DAS28 (r=−0.412, p=0.026, indicating higher levels of inflammation are significantly associated with a more hypoxic environment.

Since the DS-sarcomas show pronounced hypoxic regions with almost 50% of pO2 values below 2.5 mmHg (Thews et al, 1997), it may be that VEGF production is maximally stimulated even when animals are breathing room air, such that a further increase, due to a more hypoxic environment, might not be possible.

Disease progression can therefore relate to a more hypoxic tumour environment, higher HIF-1 alpha expression, higher plasma VEGF levels (as we have already shown, ref 10) and, finally, increased HIF-1 alpha-dependent BNP induction.

In those with distant metastases, the sharp rise in nuclear 8-oxo-dG levels may correlate with a more hypoxic tissue environment in late stage metastatic disease with upregulation of HIF-1 and VEGF levels (Jiang et al, 2003) and it is clear that rises also relate to clinical progression independent of tumour stage.

These in vitro data further support the hypothesis of Liu et al. (2001), as the chemotherapeutic agent, STX140, is equally efficacious in normoxia and hypoxia but 2DG is more efficacious in the hypoxic environment, which is hypothesised to reflect the centre of the tumour.

In general cisplatin, mitomycin c and tirapazamine were more effective in anoxic or hypoxic environment (e.g. tirapazamine was significantly more active in all evaluated cell lines; cisplatin in H69, MCF-7 and U-937; and mitomycin C in A2780, H69, MCF-7 and U-937).

"What we hypothesize is that the carbon monoxide component of the diesel exhaust is actually making that environment even more hypoxic and disrupting normal gene programming that should lead to normal septation of the aorta and pulmonary artery," says Walker.

These findings provide mechanisms by which breast tumours in a hypoxic environment acquire a more aggressive phenotype (Schindl et al, 2002).