However, the increased sensitivity to a dopamine agonist observed in that study appears to have emerged earlier than in the present study (56 days [8 weeks] vs. 12 weeks), most likely because the more prominent hypoxic state was induced by decapitation in the previous study.
It is possible that, in some organs where there is pathological fibrosis and scarring, hypoxia and HIF signaling, possibly during more chronic hypoxic states, actually drives fibrosis, which has been suggested in the case of renal fibrosis.
More recently, the hypoxic state has also been associated with reduced capacity for DNA repair, increasing genomic instability, and creation of a mutator phenotype [ 8].
These patients will typically be operated upon some months after birth, so the ex utero hypoxic state is more chronic than the acute hypoxia in these models.
The difference was statistically significant, showing a higher NSE level in patients with more hypoxic brain insult after arrest who died or remained in a persistent vegetative state.
These central hypoxic cells may be more sensitive to RF ablation because of increased cell sensitivity to heat in the hypoxic state and decreased heat dissipation due to poor tumour perfusion 57.
You don't realize how bad you feel up high, because you get used to functioning in a hypoxic state".
The air coming through the mask was even more hypoxic, like the air at twenty-one thousand feet.
Breast tumors are stiffer and more hypoxic than nonmalignant breast tissue.
By studying the climbers, six of whom reached the summit, the researchers hope to gain insight into heart failure, lung disease and sleep apnea -- all conditions related to a low-oxygen, or hypoxic, state.
