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Ideally, the next generation of treatments for nosocomial and community-acquired infections, including those caused by Candida spp, Aspergillus spp, Cryptococcus spp and Fusarium spp, will be more efficacious, with higher therapeutic indices and broader activity spectra than existing antifungal drug classes.
Iron isomaltoside 1,000 was more efficacious with higher cumulative doses of >1,000 mg IV.
In contrast, DDP followed by DXR was more efficacious with the best cell kill at a 1 h interval between each drug.
The combined regimen thus tended to be more efficacious with respect to tumour control at the expense, however, of increased toxicity which per se, eliminated a potential improvement of the overall therapeutical results.
A dose response relative to the primary end point, change in Hb from baseline to week 8, was found within group A, where iron isomaltoside 1,000 was more efficacious with higher cumulative doses of >1,000 mg.
In our study, we found treatment of live-compromised/damaged cell mixtures to be more efficacious with 100 μM of PMA, a concentration that was two- and tenfold higher than that used by Nocker et al. [ 15] and Contreras et al. [ 44], respectively.
Similar(54)
This combined with our reported observations suggest the FAM33A_1 siRNA is a more efficacious agent with a reduced off-target potential relative to the FAM33A_2 siRNA and would be the siRNA of choice for any future applications.
More efficacious therapies with fewer side effects are needed.
Thus, targeting specific mediator of inflammatory response may be more specific, more efficacious, and with fewer side effects.
Understanding the precise mechanism underlying its activity against malignant T cells may lead to better development of optimized treatment schedules and stimulate the design of more efficacious combination with other cytotoxic agents.
Thus, the higher solubility of FM-VP4 into mixed micelles may lead to a more efficacious competition with cholesterol for incorporation into the micelles, and as a consequence, a lower dose of FM-VP4 is required to realize an equal LDL-lowering effect compared with plant sterol and stanol esters.
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