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Exact(6)
They discovered that teflon decomposition not only produces TFA, but a suite of related molecules with unknown environmental effects.
The potential biological activity of small molecules with unknown functions can be predicted by the MCS-based methods.
The method has been applied in multiple projects to "de-orphan" molecules with unknown main target and investigate potential side-effects of drug candidates.
In order to register data efficiently and accurately, the UCD has the flexibility to register molecules with unknown structures or mixtures of compounds and at the same time can be used to register known structures with the precisely defined stereochemical configuration.
A few molecules with unknown function were also identified (Figure 2A).
Correlative SAR can establish new relationships between specific biochemical functions and higher-level cellular processes, particularly for proteins with multiple functions and small molecules with unknown or various modes of action.
Similar(54)
Continuous advances in instrumentation and image processing algorithms have now allowed the ribosome structure to be determined at subnanometer resolution by single-particle EM (19, 20), and for the first time the fold of an RNA molecule with unknown structure bound to the ribosome could be determined on the basis of its density in the 3D reconstruction (20).
Taken together with the extant evidence that 5′ tRNA halves can regulate mRNA translation, the characteristics of the circulating 5′ tRNA halves we have discovered suggest that they function as signaling molecules with as yet unknown physiologic roles.
In the intervening 20 years, the Committee has selected 89 agents for clinical trials: 25 cytotoxic agents, five antiendocrine drugs, 28 small molecules with novel or unknown mechanisms of action, five polymer-targeted agents and 26 antibody-targeted agents/immunotherapies.
Specific compounds have been described in detail above, but in total 89 agents have been selected, which includes 25 cytotoxic drugs, five antiendocrine agents, 28 molecules with novel or unknown mechanisms of action, five polymeric antitumour drugs and 26 antibody-targeted agents/immunotherapies.
In the course of structure elucidation of natural products we encountered a number of unknown molecules with symmetry.
Related(20)
pathways with unknown
molecules with uncertain
compounds with unknown
sequences with unknown
genes with unknown
species with unknown
elements with unknown
suspects with unknown
models with unknown
molecules with complex
molecules with different
molecules with complicated
molecules with overlapping
molecules with hERG
molecules with molecular
molecules with identical
molecules with unusual
molecules with large
molecules with high
molecules with structural
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