Some of the barley transcripts encode hordein proteins in nutrient reservoir, glycolysis pathway enzymes, proteins with unknown functions, and a number of proteins with other functions.
Pathways with a largely unknown role in GC, such as oestrogen and androgen metabolizing genes, have also been found to be associated with GC (Freedman et al. 2009).
Taking a broad view of prognostic outcomes may generate new knowledge at the start of translational pathways with (as yet) unknown implications for developing new interventions.
Metabolites with unknown pathways with their disease implications.
There are 15 medicinally relevant metabolites in Ocimum sp. with unknown pathways.
Note, however, that there exist many other carotenoids known to be produced by purple bacteria with unknown biosynthetic pathways [90]; the extent to which these carotenoids co-evolve with the photosynthetic reaction center remains unknown.
It was reported that the mTOR pathway involved in rRNA maturation with unknown mechanism (Iadevaia et al., 2012).
Of the 51 evaluable patients, 2 achieved partial responses, including 1 ER-positive, HER2-negative breast cancer patient with unknown PI3K pathway status, and 1 patient with Cowden's syndrome (germline PTEN mutation) who had developed lung cancer.
Among the 109 compounds with anti-aging activity in C. elegans, 18 with antioxidative activity, five regulating IIS pathway, four regulating AMPK, four regulating mTOR signaling, 10 regulating SIR-2.1, six regulating SKN-1/Nrf2 pathway, seven regulating JNK-1, 16 with unknown mechanisms, and about half of 109 compounds revealed to regulate multiple signaling pathways.
