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We had previously defined the pharmacophore necessary for small molecules to specifically bind and neutralize this complex carbohydrate.
The protein solution was incubated for at least 1 h at room temperature to allow protein molecules to specifically bind to the anti-histidine antibodies through their histidine tags.
The molecular basis of polypharmacology is provided by compound promiscuity, which is defined as the ability of small molecules to specifically interact with multiple targets.
In the context of polypharmacology, compound promiscuity is rationalized as the ability of small molecules to specifically interact with multiple targets.
By contrast, promiscuity also results from the ability of small molecules to specifically interact with multiple targets, and this type of 'target promiscuity' provides the molecular basis of 'polypharmacology'polypharmacology
Therefore, subsequent expression studies were performed by using PEI as the sole carrier and the three types of DNA molecules to specifically focus on the relative effectiveness of each DNA molecule for the expression of reporter gene (rather than focusing on the effectiveness of each carrier).
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Practically all biological systems rely on the ability of bio-molecules to specifically recognize each other.
Compound promiscuity is defined as the ability of a small molecule to specifically interact with multiple biological targets.
One of the major challenges in metabolomics is validation of fingerprint molecules to identify specifically perturbed pathways in metabolic aberrations.
Based on the role of DDX3 in proliferation and as a potential marker of aggressive cancer, we rationally designed small molecules to bind specifically to the ATP-binding cleft of DDX3 (Kondaskar et al, 2010).
MiRNA mimics are small, chemically modified double-stranded RNA molecules designed to specifically bind to and mimic endogenous miRNA molecules.
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