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The generation and release of fragmented molecules could generate novel biochemical markers with the capacity to monitor disease progression, facilitate drug development and add to the existing toolbox for in vitro studies, preclinical research and clinical trials.
The time of flight secondary ion mass spectroscopy (ToF-SIMS) also revealed that the side-chain scission from the APTMS molecules could generate amine and amide fragments, which could hinder the polymerization of the SiOx.
We assessed whether such circular viral molecules could generate LTR-LTR transcripts during PFV replication.
Further recombination/ligation events between such simple RNA molecules could generate templates encoding sufficiently complex protein products (primordial mRNAs).
We then determined whether the fusion molecules could generate FRET signals that were sensitive to cleavage (Fig. 2A).
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As far as we know, hydrolytic process of proteins by proteases could generate molecules ranging from individual amino acids to peptides of various sizes and peptide length was thought to be closely related to biological activities.
However, because of the functional centrality of these targets and their large impact on protein network architecture and robustness we can anticipate that drug designed on this rational could generate molecules with high toxicity.
Our results showing high expression of three PG genes prior to fruit ripening is the first evidence at the transcript level of possible increases in cell wall degradation enzymes that could generate signal molecules from cell wall fragments to stimulate the development of ripening capacity in European pears.
Among the chosen LMHCs, glycerol molecule which has three hydroxyls could generate the most hydroxyl radicals and contribute the best effective promotion.
Processing of such a long hairpin structure could generate miRNA-like molecules detected in our study (Additional file 1: Figure S5C).
A series of genes that could generate relevant biologic molecules to form vascular channels were observed to be downregulated with celecoxib treatment, including fibronectin, collagen, and laminin.
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