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These findings suggest the specific deletion of these target genes could generate a safe and efficacious live attenuated vaccine.
Protein-coding genes could generate transcripts from lncRNAs genes.
These data provide evidence that two linked genes could generate a bistable differentiation.
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We have recently shown on human cell lines that choosing an unstable internal control gene could generate dramatic misinterpretations (Caradec et al, 2010a).
Our molecular analysis of the delorean allele using 5′ RACE aimed to determine how a transposon insertion within the first intron of the pkn gene could generate a mutant phenotype.
A series of genes that could generate relevant biologic molecules to form vascular channels were observed to be downregulated with celecoxib treatment, including fibronectin, collagen, and laminin.
Variations in peptide processing have also been shown by proteomics and transcriptomics to explain how a limited set of genes transcripts could generate thousands of toxins in a single species of cone snail [ 461].
One obvious implication from our work is that many potential gene fusions could generate the same combination of domain architectures, because each architecture is usually encoded by several genes.
We therefore conclude that in cases like these, a single copy number change in a TSPY-related sequence (curCNVE5) or an RBMY gene (curCNVE16) could generate the observed signal because of cross-hybridization.
In the present study, we show that a mechanistic, systems-level computational model of the B cell transcriptional network incorporating stochastic gene expression could generate dose response curves for a broad range of doses in agreement with experimental measurements.
The wp pink flower mutation of soybean that we describe offers an example of how a transposon insertion in the intron of the wild-type gene (F3H1) could generate an array of alternatively spliced transcripts with potential to be translated into novel proteins without totally losing the ability to synthesize the wild-type transcript and encoded protein.
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