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Local molecular motions at low temperatures occurring in collagen molecules could enhance bone toughness.
These data indicate that co-treatment with highly cationic molecules could enhance the efficacy of ribonucleases as chemotherapeutic agents.
It was found that a good rebinding solvent should have less affinity with both template and polymer and a good solubility, and a large self-association among solvent molecules could enhance the affinity between template and MIP.
In our previous study, we found that several specific small molecules could enhance the endodermal conversion process, including CHIR99021, NaB, Parnate, RG108, and 5'-N-ethylcarboxamidoadenosine, and promote pancreatic β-like cell differentiation and maturation, including Compound E, Vitamin C, and Bayk8644 (Zhu et al., 2016).
Furthermore, the development of novel synthetic analogs of these natural molecules could enhance their activities, facilitating the development of new drugs.
Our studies with mutant LPS structures provide novel evidence that these molecules could enhance osteogenesis and thereby have a potential to restore bone homeostasis during inflammatory bone diseases.
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Although in the present study we did not observe any antibacterial activity by lactoferrin when tested alone, in our previous studies we showed that in the solution assay this molecule could enhance the effect of lysozyme and defensins against respiratory pathogens [ 13].
By following this rational design concept of targeting multiple structural water molecules as binding partners for small organic molecules, we could enhance the binding affinity of our rationally designed phthalimide scaffold by a factor of 20.
We sought to identify small molecules that could enhance the activity of p53 by combining the mdm2/p53-binding antagonist Nutlin-3 with small molecules known to modulate p53 function.
The composite surface could attract positive charges at a lower pH [29], and the powerful electrostatic bond between the positive and negative charges of composite and dye molecules, respectively, could enhance dye adsorption.
The researchers now plan to perform larger screens for molecules that could enhance heart repair in zebrafish, and perhaps one day provide a new treatment for humans with heart conditions.In a second paper appearing April 1, 2015, in the journal eLife, Poss and colleagues found that the epicardium produces a molecule called neuregulin1 that makes heart muscle cells divide in response to injury.
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