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We show here that MHC class II molecules can play a key role in innate immunity by enhancing TLR-mediated cellular activation and antimicrobial effector mechanisms.

Another question is whether bile acids or other related molecules can play an anti-aging role in metazoans.

The higher level of AGE found in patients with post-infarction HF showed the pathophysiological role that these molecules can play in ventricular remodelling.

One consequence of the valence matching rule is that water, and sometimes other molecules, can play an important role in stabilizing a structure.

The secreted molecules can play an important role in cellular homeostasis and even in bacterial lifestyles: some are literally injected into host cells in which they modify host physiology to promote colonization.

When multicomponent adsorption needs to be considered (i.e. separation through membranes), due to the relatively high concentrations of adsorbates, interactions between molecules can play a significant role in terms of 'speeding up' or 'slowing down' other components.

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Another major group of secreted molecules that can play a role in virulence are siderophores.

MicroRNAs (miRNAs) are small (approximately 22 nucleotides long) endogenous noncoding molecules that can play important regulatory roles in animals and plants by targeting mRNAs for cleavage or translational repression.

In this process, a membrane-bound protein is cleaved, liberating a soluble messaging molecule that can play a role in a variety of cellular processes, including apoptosis, lipid metabolism and the response to viral infection (Lal and Caplan, 2011).

This review discusses the many roles atomistic computer simulations of macromolecular (for example, protein) receptors and their associated small-molecule ligands can play in drug discovery, including the identification of cryptic or allosteric binding sites, the enhancement of traditional virtual-screening methodologies, and the direct prediction of small-molecule binding energies.

We show that the helical character of the molecule, possibly supercoiled, can play a key role in many denaturation and renaturation processes.

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