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Both molecules can regulate insulin secretion from beta cells [5], [6].
► Fatty acid derived molecules can regulate inflammation through PPARs.
It is therefore not surprising that certain canonical apoptotic molecules can regulate autophagy, and vice versa.
Quorum sensing molecules can regulate human transcriptional programs to the advantage of the pathogen.
As transcription factors, Gli molecules can regulate target gene expression by direct association with a specific consensus sequence located in the promoter region of target genes [8], [9].
Zheng et al. also uncovered a novel mechanism by which mRNA molecules can regulate gene expression independent of their role as templates for proteins.
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Thus, an unsolved question is how the same signalling molecule can regulate such distinct cell processes as proliferation, cell survival and differentiation.
Functional studies on mammalian and zebrafish Dact2 showed that this molecule can regulate both Wnt and Tgfβ signaling [ 6, 7, 18].
There must be other mechanisms, such as the availability of other regulators, co-factors or signaling molecules, that can regulate the responsiveness of PPARγ.
An equally important goal of synthetic biology, chemical biology, and personalized medicine is to devise molecules that can regulate genes and networks in a programmable manner.
MicroRNAs (miRNAs) are short (19 25 nt), noncoding RNA molecules that can regulate their target gene expression post-transcriptionally [5].
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