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The geometrical relationship between interacting residues provides valuable insights into the process of protein folding and would be useful for the design of protein molecules and modulation of their binding properties.
Among the different components of the immune response, lymphocytes are essential in the organism's defence against external aggression, by interaction (T cells) with antigen-presenting cells and subsequent activation of the immune response (B and T cells), in a complex interplay of cell-to-cell interactions, production of adhesion molecules and modulation of growth factors [10].
Even though not fully understood, suggested mechanisms behind the described beneficial effects of intravenous vitamin C treatment, in both sepsis and burns, are scavenging of reactive oxygen species, reduction of endothelial adhesion molecules and modulation of nitric oxide production [3, 13 15].
HCMV infection provokes a proinflammatory response characterized by an increased expression of chemokines, adhesion molecules, and modulation of angiogenesis, which in turn promotes progressive HCMV infection.
Indeed, 17β-estradiol has been shown to affect several processes involved in the pathogenesis of RA, including immunoregulation, regulation of adhesion molecules, and modulation of cytokine signaling.
Instead of activating the "master genes" by virus transfection, pluripotency and reprogramming network can be reestablished by the application of small molecules and modulation of cell culture microenvironment.
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Our results indicate that recognition of 3' splice sites involves different U2AF-like molecules, and that modulation of these general splicing factors can have profound effects on splicing.
Hyperglycaemia-induced expression of adhesion molecules and the modulation of junctional permeability is one of the initial events of endothelial dysfunction and was recently shown to be mediated by the PKC pathways.
One structural class that has largely evaded small molecule recognition and modulation is the ankyrin repeat.
Thus, overproduction of viral attachment molecules and its resulting modulation of viral receptors may contribute to control the natural infection course of various viruses.
This stochastic super-resolution technique features two typical properties: the stochastic emission from single fluorescent molecules and the temporal modulation of the emission.
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