Sentence examples for pathways and modulation from inspiring English sources

This axis describes a bi-directional communication system and comprises neuronal signaling, neuroendocrine pathways and modulation of immune responses.

Hsp27 and clusterin (CLU are stress-activated small heat shock proteins that are up-regulated in many cancers where they play important roles in stress-induced protein homeostasis (proteostasis), inhibition of cell death pathways, and modulation of pro-survival signaling and transcriptional networks.

The differential and temporal requirement of PI4KCA during infection by F. tularensis suggests modulation of PI4KCA-dependent signal transduction pathways and modulation of phosphoinositide metabolism by F. tularensis are triggered after phagosomal escape and initiation of bacterial proliferation within the cytosol.

Omega-3 PUFAs may have beneficial effects on insulin action through several mechanisms, including by improving membrane fluidity, production of antiinflammatory eicosanoids, affecting key proteins in signal transduction pathways and modulation in expression of peroxisome proliferator activated receptor γ (20).

We have shown that EGFR activation in ERα- breast cell lines is associated with Jab1 nuclear localization and that these changes relate to activation of both AKT and ERK pathways and modulation of Jab1 downstream genes.

These findings emphasise the complexity of control of E-cadherin in breast carcinomas and provide evidence of a link between membrane signalling pathways and modulation of E-cadherin expression.

Our results indicate that the mechanism involves inhibition of the PI3K/Akt pathway, and modulation of the TRAIL receptor DISC components FLIPS and DR5.

We have previously shown that hypoxia can lead to activation of the NF-κB pathway, and modulation of NF-κB transcriptional activity in mammalian cells [ 24, 25].

TGF-β signaling is tightly regulated at different levels along the pathway, and modulation of TGF-β receptor activity is a critical step for signaling regulation.

Promotion of cardiomyocyte proliferation through activation of the Yap pathway and modulation of epicardial signaling systems have shown efficacy in enhancing these processes.

Some studies showed that resveratrol exerted its cardioprotective effects through multiple mechanisms including activation of AMPK pathway and modulation of calcium handling proteins [ 38, 39].