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Cell-wall polysaccharides can be analysed using fluorescence microscopy after labelling with a green fluorescent protein tagged carbohydrate-binding molecule specific for cellulose (Lacayo et al. [2010]).

If an enzyme is conjugated to a targeting molecule specific for some analyte of interest, then an assay system can be constructed to localize or measure the analyte.

Their structure is based on the pentasaccharide region of the heparin molecule specific for antithrombin binding: they lack the longer saccharide chain that neutralizes thrombin.

The goal was to search for any chemical differences between the sites that could be exploited to design a molecule specific for Plk1 PBD that would not bind LYN or any other kinase.

Targeting two tumour-associated antigens as a mechanism for modulating signalling within the tumour cell to elicit a therapeutic effect was validated by Zu and colleagues using a single-gene bs-diabody molecule specific for VEGFR2 (KDR) and VEGFR3 (Flt-4).

Similar(55)

Affibody molecules specific for H-Ras and Raf-1 were evaluated for their ability to inhibit synovial cell function.

These findings suggest that affibody molecules specific for H-Ras and Raf-1 can affect intracellular signal transduction through the MAP kinase pathway to inhibit cell proliferation and production of inflammatory mediators by synovial cells.

Several different cell adhesion molecules (CAM's) have now been found in a number of vertebrate species in different tissues such as liver and striated muscle and even in a single complex structure such as the brain, where different molecules specific for neurons and glia have been identified.

Recently, several ER membrane molecules specific for certain cell types have been identified.

To definitively demonstrate a role for SLK in cell migration, we transfected small interfering RNA (siRNA) molecules specific for murine SLK into MEF-3T3 fibroblasts and assayed their migration in a transwell assay.

Fluorescent probes that target molecules specific for breast cancer are currently being developed and validated in preclinical animal studies.

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