Sentence examples for compound specific for from inspiring English sources

This approach has significant promise and may be more effective than using one compound specific for one drug target or, by a polypharmaceutical approach, using a cocktail of two or more drugs.

Maximal inhibition of IGF-I-stimulated phosphorylation of Akt S473 was obtained at a concentration of 10 μM using a compound specific for Akt ("Akti;" ref. (28)).

We found that blocking HDAC3 activity using MI192, a compound specific for HDAC3, modulated tubulin acetylation in the human prostate cancer cell line PC3.

These advantages demonstrate that bacterial clones expressing membrane receptors constitute an alternative screening procedure for synthetic compounds specific for each β-adrenergic receptor subtype.

Compounds specific for smoking were not included in these sets.

However, compounds that inhibit Sirt2 and another isoform might still be developable into compounds specific for the other isoforms.

To take side chain flexibility into account, however, might be an approach for identifying compounds specific for the other isoforms studied here, Sirt3, 5, and 6 [ 40].

This has the potential to allow the design and use of compounds specific for one HDAC (or a small number of HDACs), which may be crucial in avoiding toxicity in vivo.

Our family-wide structure-based approach thus identified potent, Sirt2-specific inhibitors as well as lead structures and a target site for the development of compounds specific for other Sirtuin isoform, constituting an important step toward the identification of a complete panel of isoform-specific Sirtuin inhibitors.

The mode of action and the causative agent(s) (i.e., parent compound, specific metabolite) for these noncancer effects are not known.

Wild type animals as well as sod2 nullizygous mice were treated to control for compound specific effects.