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Cases of sCJD were classified according to Parchi et al. that identified six molecular subtypes on the basis of the PRNP codon 129 polymorphism and PrPres type [7].
This study describes the influence of BC molecular subtypes on risk of death in a Hispanic population.
This is the most comprehensive study to date on the impact of BC molecular subtypes on BC survival in Puerto Rico.
First, the molecular differences that exist between breast cancers (Perou et al, 2000; Pollack et al, 2002; Desmedt et al, 2004) support treating different molecular subtypes on the basis of their biology and pathology rather than on pathology alone.
Many organ-specific cancers have established definitions of molecular subtypes on the basis of genomic, transcriptomic, and epigenomic characterizations [ 1– 3], indicating diverse molecular oncogenic processes and clinical outcomes.
Our ongoing follow-up with the cohort would overcome this limitation and allow an examination of the long-term effects of different molecular subtypes on the survival of breast cancer patients.
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This study is the largest population-based study on molecular subtypes of breast cancer and survival among Chinese women.
The effect of molecular subtyping on current treatment decisions is limited to avoidance of adjuvant 5-fluorouracil chemotherapy in stage II microsatellite unstable-high disease and avoidance of epidermal growth factor receptor-targeted antibodies in extended RAS mutant tumours.
The relative frequency of molecular subtypes in DCIS vs invasive disease provides some insight into the impact of molecular subtype on progression.
The web application bc-GenExMiner [ 17] was used to compare the mRNA levels within each breast cancer molecular subtype on a dataset comprising 1210 microarrays.
However, the effect of molecular subtype on the survival advantage conferred by screen detection was not assessed in this analysis [ 29].
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