Following the work by Sørlie and colleagues that presented the intrinsic molecular subgroups of BC based on gene expression patterns, a substantial amount of information has elucidated the complexity in pathways driving the different BC subgroups.
Taken together, these results indicate that the establishment of molecular subgroups of CRC based on KRAS and BRAF mutation status can supply important information, not only in prediction of the EGFR-treatment response but also in prediction of patient prognosis.
In this prospective study, we observed that the intake of total, saturated and monounsaturated fat was not associated with the risk of colon cancer, rectal cancer, or the different molecular subgroups of cancer based on lack of MLH1 expression or truncating mutations in the APC gene.
66 Predictive studies for newer targeted therapies, such as EGFR inhibitors and anaplastic lymphoma kinase inhibitors, have focused on selected molecular subgroups of NSCLC and have shown predictive biomarkers for these therapies; however, these studies were not included in this review because the mutations/biomarkers are genetic factors.
So far, studies on associations of HRT and molecular subgroups of CRC have been limited and inconsistent [ 15- 17].
This bias is less evident when the authors focus on well-characterised cytogenetic and molecular subgroups of AML.
Taylor, M. D. et al. Molecular subgroups of medulloblastoma: the current consensus.
Kool, M. et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas.
Integrating genomic technologies with clinical trials to define molecular subgroups of patients who are most likely to respond to therapy.
Molecular subgroups of medulloblastoma: the current consensus.
