Sentence examples for molecular pathways targeted from inspiring English sources

Therefore, we investigated the underlying molecular pathways targeted by distinct PPAR-γ ligands to explore the potential of PPAR-γ agonists as anti-fibrotic therapies.

These data suggest that while the general pathways are related to cancer, the specific molecular pathways targeted by the deregulated miRNAs are variable and depend on each miRNA.

Hence, the constructed network clusters complemented the results of our GO analysis by facilitating detailed insight into the molecular pathways targeted by carcinogenic expression changes.

This analysis therefore suggests that while the general pathways affected by miR-34c, miR-98, miR-424, and let-7f expression in these two cell lines are related to cancer, the exact molecular pathways targeted are variable and depend on the cell line and on the miRNAs.

There are a number of studies suggesting that botanicals are anti-inflammatory [ 29– 36] 36]; however, the molecular pathways targeted by many of these remains poorly defined.

Modeling initiatives will need to follow a multiscale strategy, integrating data and information from the molecular level (molecular pathways targeted by the investigated compounds), through the cellular level (cell cycle regulation), to the macroscopic level (tumor dimensions).

Next, we sought to identify the molecular pathway targeted by VPA in blocking 5HT neuronal differentiation.

Taken together, these results highlight the pleiotropic effects of rapamycin, making it difficult to fully resolve the contribution of each molecular pathway targeted by its action.

After this introduction, the book discusses chemotherapeutic compounds by class, in a manner reminiscent of more clinically rich clinical oncology texts: anti-metabolites, DNA interactive, anti-tubulin, molecular pathway targets and hormonal pathway targets.

Alcohol has an array of molecular pathway targets and modes of inducing apoptosis and the candidate disease genes selected using this method have a strong role to play in apoptosis.

While these data confirm suppressive effects of MV on activated T cells, a better understanding of the molecular mechanisms and signalling pathways targeted by MV/exosomes are necessary.