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Molecular diagnostics with high sensitivity and specificity are essential for the early detection of infectious diseases caused by pathogens.
In recent years, isothermal amplification methods have become a useful alternative to polymerase chain reaction (PCR), allowing molecular diagnostics with simple or no instrumentation.
Molecular epidemiological methods using the power of WGS that parallel molecular diagnostics with direct application to complex specimens are needed.
Proportional hazard models were used to determine the univariate prognostic significance of clinicopathological variables and molecular diagnostics with respect to local and locoregional recurrence.
The discovery of the HFE gene in 1996, the high prevalence of C282Y mutations, and the morbidity and mortality associated with untreated hereditary haemochromatosis have presented molecular diagnostics with a potentially attractive test for population screening.
Non-small cell lung cancer and melanoma are at the forefront of molecular diagnostics, with a variety of treatments targeting molecular alterations defining specific cancer subtypes (e.g., BRAF, EGFR, ALK alterations).
Similar(54)
VLs were measured using the reverse transcription PCR method (AMPLICOR HIV-1 monitor test, Roche Molecular Diagnostic), with a detection limit of 50 copies/ml, according to the manufacturer's instructions.
"Our combined company will be well positioned globally to capitalize on the fast-growing molecular diagnostics market with an established global infrastructure".
Bale jokes that the personality best suited for molecular diagnostics is one with obsessive-compulsive disorder, explaining, "You have to be vigilant and very careful.
However, molecular diagnostics is faced with its own specific challenges.
Molecular diagnostics for patients with retinitis pigmentosa (RP) has been hampered by extreme genetic and clinical heterogeneity, with 52 causative genes known to date.
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