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Realizing this vision requires interfacing natural molecular inputs with synthetic components that generate functional molecular outputs.
Therefore as shown in Fig. 1B our supramolecular system is designed to respond to two different molecular inputs with a reversible change and, in addition, can potentially undergo multiple cycles.
Here, we report a BTA supramolecular polymer that changes its monomer sequence in response to two different molecular inputs with: (i) a multivalent anionic nucleic acid able to cluster specific monomers into a block copolymer-like conformation and (ii) an RNAse enzyme able to degrade the recruiter and restore a random copolymer distribution.
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Conversely, what are the molecular inputs that drive differentiation?
Two molecular inputs to control supramolecular copolymer sequence: towards molecular design of synthetic supramolecular networks.
Chemists, with their Simplified Molecular Input Line Entry System (SMILES) representation of chemicals, provide us with a concrete illustration (Karwath & De Raedt, 2006).
Such a system would no longer need a thermal annealing step to initiate the assembly and encourage the dominance of the desired, lowest-energy product; the reaction could instead proceed isothermally and in situ with a molecular input to trigger the assembly.
In-silico structures were generated by replacing the SQDG core structure with GlcADG in the SMILES (Simplified Molecular Input Line Entry System) structure codes using text based find-and-replace in Microsoft Excel.
The QSAR models were calculated with the representation of the molecular structure by simplified molecular input-line entry system and by the molecular graph.
QSAR models were calculated with the representation of the molecular structure by the simplified molecular input-line entry system.
simplified molecular input line system.
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