Sentence examples for molecular alterations characteristic from inspiring English sources

Literature suggests that 18F-FDG PET scanning might be useful in displaying molecular alterations characteristic of the weakening of the AAA wall.

Interrupted minigenes have been shown to reproduce molecular alterations characteristic of DM1, in particular missplicing of cardiac troponin T [34] and colocalization with Muscleblind in the cell nucleus ([35], [5]; this work).

Using immunohistochemistry (IHC) to localize MYC expression in Lo-MYC transgenic mice, we show that morphological and molecular alterations characteristic of high grade PIN arise in luminal epithelial cells as soon as MYC overexpression is detected.

Cells that are more phenotypically invasive, as well as those that show molecular alterations characteristic of invasive potential, show a greater propensity to metastasize [ 50].

Early appearance of several molecular alterations characteristic of EMT has been described in benign adenomas of the multiple intestinal neoplasia (Min) mouse model of familial adenomatous polyposis disease (Chen et al. 2008).

These results prompted us to hypothesise that this could be a molecular alteration characteristic of the advanced stages of CRC that could therefore have a prognostic value in patients with metastatic disease.

These serrated polyps include not only hyperplastic polyps but also traditional serrated adenomas and sessile serrated adenomas: these polyps demonstrate characteristic molecular alterations not commonly seen in colorectal adenomas, and they probably progress to colorectal cancer by means of a new pathway: the serrated neoplasia pathway [ 31].

In this study, we analyzed the morphological characteristics, molecular alterations, and biological behavior of pancreatic wild-type and neoplasia tissues, including analysis of PanIN cell line SH-PAN (isolated from Pdx-1-Cre; LSL-KrasG12D/+ mouse) and PDAC cell line DT-PCa (isolated from Pdx1-Cre; LSL-KrasG12D/+; LSL-Tp53R172H/+ mouse).

Based on clinical behaviour, morphological characteristic and molecular alterations EOCs have been recently divided in two types (type I and type II; Kurman & Shih, 2011), with type II EOC representing a lethal neoplasia with the highest death-to-incidence ratios (Jemal et al, 2011).

Both standard two-primer amplification and four-primer microfluidics PCRs yielded highly linear characteristics in detecting molecular alterations in series of dilution experiments.

To investigate the role in predicting the response to primary chemotherapy, all tumour characteristics (histological parameters and molecular alterations) were compared to clinical and pathological outcome in our series.