Using immunohistochemistry (IHC) to localize MYC expression in Lo-MYC transgenic mice, we show that morphological and molecular alterations characteristic of high grade PIN arise in luminal epithelial cells as soon as MYC overexpression is detected.
Thus, oncogenic EMT could be defined as an EMT-like process in which carcinoma cells gain mesenchymal-like characteristics and/or lose epithelial characteristics; morphological alterations may or may not accompany such changes (see 'Breast cancer EMT mediators' section for further discussion).
The aim of this study was to investigate the characteristic morphological alterations of lung tissue after experimental App challenge using computed tomography in pigs.
ASH leads to characteristic morphological alterations in the liver, such as accumulation of fat (steatosis), ballooning of hepatocytes, appearance of hepatocytic protein aggregates (Mallory Denk Bodies), necrosis and apoptosis, fibrosis, inflammation, and cholestasis.
The most characteristic are morphological alterations (17, 18).
Accordingly, one must be careful to avoid interpreting normal interindividual characteristics as morphological alterations, or changes as a consequence of a medical treatment or any other factor.
Morphological alterations may also be related to the patient and the cycle characteristics, and may involve most or all oocytes in the cohort.
Alterations in protein secretion, intracellular signaling, and cell morphology were monitored; and the role of integrin signaling in MSeA-induced morphological alterations was investigated using divalent cation treatments.
Schuetze, M. et al. Morphological Alterations in the Thalamus, Striatum, and Pallidum in Autism Spectrum Disorder.
In addition, morphological alterations were observed on the surface of the host cells infected by the mutants.
The expression of such morphological alterations is associated with genomic instability.
