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Exact(33)
There are only one or two modules identified in the thymus in both species.
This was done by selecting modules identified in the previous step that were associated with the compound and overlaying them on the disease-specific IMCN (Figure 1f).
The main set of network modules identified in glioblastoma is shown in Figure 2. From these modules, we can make two initial observations.
It is also possible that the expression of the 6200 genes has tissue sampling bias, leading to more modules identified in some of the tissues.
We used both randomization methods and direct comparisons of landmark variance to compare disparity in the six cranial modules identified in previous studies.
In addition the present study focuses on the most significant network modules identified, however some of the proteins identified in [24] were found among less significant modules identified in the present study (data not shown).
Similar(27)
The "black" module in adipose of AA subjects overlapped significantly with the "light yellow" module identified in CA subjects.
In addition to strong functional enrichment illustrated by protein-protein interactions, the midnight blue module was also the most highly connected and conserved module identified in the PAG.
Despite this finer granularity, the physiological functions annotated for each module identified in this work highly correlated with the corresponding functions for the submodules identified by the NDA.
To assess the significance of functional clusters, we created 22 sets of 11,191 probe sets corresponding to 8,036 genes (size of the average module identified in this study).
Because of its extreme conservation, the SPS+A module identified in CNS1 provides an ideal experimental system to investigate the regulatory significance of this DNA and its potential impact on species-level expression differences.
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