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The common high scoring nodes identified in all the population were: TP53, SRC, ESR1, SMAD3, GRB2, EP300, CREBBP, EGFR, SMAD2, and CSN2KA1.
All nine nodes identified in our 10-edge pattern subgraph are associated with the cancer disease with glucocorticoid receptor (GR) as the central molecule.
Although HIF is one of the key nodes identified in our interactome, applying network analysis to address in vivo angiogenesis is still challenging.
The mean and median numbers of nodes identified in the mild and prominent lymphocytic infiltration groups were compared and the significance of the difference tested using a Mann–Whitney U test.
c) StructureLayerNode The purpose of this procedure is to arrange the candidate child nodes identified in FindLayerNode into a sub-tree structure using the nodes currently in the bottom layer of the current branch as potential parent nodes.
The set of nodes identified in this way is a minimal node separator, but it is not necessarily good, because it may contain nodes with incident backward edges see Section 2.1.
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TP53, the other tumor suppressor node identified in our analysis, is among the most frequently mutated tumor suppressors in cancer with mutations occurring in most human tumors.
For breast cancer cell lines, the claudin-low subtype classification was based on unsupervised hierarchical clustering using the intrinsic list of Parker et al. [ 9] and the node identified in Figure S4 in Additional file 1.
The overall pattern of greater survival with more nodes identified persists in the sub-group where data on lymphocytic infiltration were available, although it does not reach statistical significance.
In order to be compared with the result in the paper [ 10, 11], frequent probability subgraph with 3-4 scale nodes and 5 scale nodes were identified in S.cere 1 and S.cere 2 separately.
The unique nodes identified based on both features in Table 3 were ABL1, GL11, CDC6, ESR2, MK11, and PIAS1.
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