Sentence examples for modulation of integrins from inspiring English sources

Whether or not Akt is important for the affinity modulation of integrins that mediate their switch to the invasive and metastatic cells is not yet known.

One important aspect that our manuscript does not address is the molecular mechanisms by which Akt mediate affinity modulation of integrins in prostate cancer cells.

The multiple effects include direct inhibition of myeloma cell growth and survival, direct stimulation of the cellular immune system, modulation of integrins compromising the adhesive interactions between the myeloma cells and bone marrow stroma, and antiangiogenic effects [ 23– 25].

The increased aggressiveness of astrocytomas is accompanied by the acquisition of cellular migratory potential [ 18], from the modulation of integrins and their receptors expression with an increase of lamellipodia cytoplasm extensions and diminution of focal adhesion to the extracellular matrix [ 43].

The mechanism of action of the mobilizing factor granulocyte colony stimulating factor (G-CSF) is complex and involves cleavage of stromal-derived factor (SDF -1α through releaSDF -1αrothrough elastases, and matreleaseallofrotease-9, suproteases of ostelastases function, and matrixtion of integrins (10).

Further, we evaluated the targeted modulation of integrin expression in combination with cryoablation on human prostate cancer cell death.

In addition, modulation of integrin signals, by adding collagen IV or RGD-peptide, significantly affected the EPS-induced development of contractility.

Modulation of integrin-mediated focal adhesion and related cell signaling by altering nanoscale substrate topography will have powerful applications in biomaterials science and tissue engineering.

Does it involve modulation of integrin and/or growth factor receptor function?

Next, we investigated whether modulation of integrin αv β3 has any effect on transendothelial migration of prostate cancer cells.

Interactions of focal adhesion proteins with integrins are important for focal adhesion formation and maturation, modulation of integrin-ligand binding affinity and ECM remodeling [ 11, 12].