By contrast, the usefulness of simple and high-throughput screening tests for the detection of cognition enhancers might be restricted to advanced drug-finding programs that are guided by evidence of the modulation of neurocognitive relationships by cognition enhancers and that are informed by iterative preclinical clinical cross-validation of research approaches.
Therefore, potential exists for modulation of these relationships in populations with different exposures from diet, including in those not exposed to folic acid fortification programmes.
Our data are consistent with earlier studies about genetic effects on modulation of the relationship between mesencephalic dopamine and prefrontal cortex activity [103].
Moreover, the main objective of the present fMRI data was to evaluate statistically significant DRD2 modulation of the relationship between striatal dopamine D2 signaling with prefrontal activity during performance of working memory which should not be affected by the corrected significance of the above mentioned DRD2 effect.
For example, adaptation with a time constant of decay that depends on the size of the onset transient, along with modulation of this relationship (between transient and time constant) that further depends on the transient response level might replicate some of the dynamics seen in this individual data set.
Through their modulation of the relationship between a protein's primary sequence and final structure that is, between genotype and phenotype chaperones have been proposed to facilitate the adaptive evolution of their client proteins (Rutherford and Lindquist 1998; Fares et al. 2002; Queitsch et al. 2002; Tokuriki and Tawfik 2009a, 2009b; Lindquist 2010).
In addition, default network exhibited decoupling with several task positive networks, consistent with methylphenidate modulation of the competitive relationship between these networks.
The neural networks illustrate the local time, seasonal, and storm modulation of the nearly linear relationship between Dst and ΔH.
In 4 studies [ 26– 29], the effects having the highest occurrence were related to modulation of prolactin release (12 NMDR relationships) and changes in protein kinase activity (11 NMDR relationships) in pituitary cells.
However, controlling for average magnitude of activity did not affect the relationship between modulation of activity and performance.
