Sentence examples for modulation of function from inspiring English sources

Pharmacological intervention of several neuropsychiatric and neurologic disorders essentially relies on the modulation of function of the DRD2 receptor.

These small, synthetic, homogeneous molecules bind in the GAG-binding site of proteins resulting in modulation of function.

Interestingly the causative variant of TSA1 does not result in a loss or gain but shows a modulation of function.

ULK3 regulates the timing of abscission through phosphorylation and modulation of function of a member of the ESCRT complex protein IST1.

The IKK complex may be a good target to specifically interfere with NF-κB activation in TRAIL-resistant cancer cells, such that gene therapy strategies involving exogenous TRAIL expression with concurrent inhibition of the NF-κB pathway through IKK modulation of function may extend the therapeutic index of TRAIL for patients with lung cancer.

There already exists evidence for post-translational modulation of function for the eEF1As; phosphorylation at S300 by TGFbetaR-1 was shown to prevent aa-tRNA binding to eEF1A1 [ 12], and mono- O-glucosylation at S53 in eEF1A is known to inhibit protein synthesis [ 13].

Another important factor in the modulation of functioning could be the source of emotion (internal vs. external) with regard to a physical cause of emotions or feelings.

Thus, structural modifications of the "main door" appear to permit modulation of enzymatic function that does not necessarily lower function for other substrates.

These findings support a role for TNFα modulation of endothelial function, such as leukocyte adhesion and angiogenesis.

Mst1 mediates cardiac troponin I phosphorylation and play a critical role in the modulation of myofilament function in the heart.

The aim of this study was to investigate the intracellular function of SLPI and the mechanism-based modulation of neutrophil function by this antiprotease.