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It was long thought that the predominant A1 receptor-meditated modulation by endogenous adenosine was a homeostatic process intrinsic to the synapse.

While differences of If/IHCN conductance in part might be caused by distinct recording techniques or by the expression of different HCN channel isoforms, it might also indicate HCN modulation by endogenous KCR1 within native channel complexes.

Uryu and colleagues [ 40] observed the analgesic effects of moxibustion on an experimental KOA rat model and found that repeated moxibustion treatments for pain relief correlated with sustained inhibitory modulation by endogenous opioids.

The induction of LTP thus not only depends upon the parameters of conditioning stimulation and the type of afferent fibres involved, but also upon the modulation by endogenous pro- and antinociceptive systems.

This action is endothelium-independent and is different from the vasodilator effects of angiotensin II inhibitors and calcium channel blockers, which are subject to modulation by endogenous NO release in the vasculature.

Similar(55)

To assess the modulation by E2F of endogenous EBP1 expression, we transiently transfected MCF-7 and HEK-293 cells with vectors encoding E2F1, and measured EBP1 mRNA abundance 24 h after transfection by quantitative real-time PCR.

Furthermore, in another study [ 12], we have shown that: 1) kallikrein causes a decrease in O2 consumption in cardiac muscle from normal dogs, which is mediated by kinin and NO mechanisms; and 2) the modulation of O2 consumption by endogenous NO is depressed in cardiac muscle from diabetic dogs, whereas the modulation of O2 consumption by exogenous NO is still preserved.

Thus, modulation of hepcidin expression by endogenous BMPs does not seem to underlie the reduction of hepcidin mRNA by DMOG and DP.

Notably, single-channel properties of native If in control cells more closely resembled those of heterologously expressed HCN2+KCR1 than of IHCN2 alone (Figure 6A, Table 2), indicating a possible modulation of HCN subunits by endogenous KCR1 in native cells.

In our previous studies [ 12], we have shown that there is depressed modulation of O2 consumption by endogenous NO in cardiac muscle from diabetic dogs.

As a corollary to this suggestion, modulation of GABAAR function by endogenous neurosteroids may be important in "fine tuning" HPA axis function.

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