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A growing literature indicates that visual cortex areas viewed as primarily responsive to exogenous stimuli are susceptible to top-down modulation by selective attention.
Initial target validation requires evidence for modulation by selective probes.
This response modulation by selective attention does not occur during the initial transient response but develops after an additional delay.
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It thus appears that enhancement of overall cell migration by different pro-migratory genes can be achieved by selective modulation of a variety of dynamic cellular features such as cell polarization and protrusive membrane activity.
Considering that both GLP-1 receptor and ERα are highly expressed in the VMH (Shughrue et al., 1997; Gu et al., 2013) raises the possibility that the metabolic benefits of E2 and GLP-1 agonism may be mediated by selective modulation of AMPK in the VMH.
The slow kinetics of the rising and decaying phase of α10/0 eIPSCs, together with their sensitivity to modulation by the δ-selective compound DS2 (Wafford et al., 2009; Herd et al., 2013; Jensen et al., 2013), indicate that such residual events are mediated by recruitment of δ-containing extrasynaptic (e GABAARs in response to nRT spike bursts.
Whether a similar fine modulation of SM and GSLs by selective replenishment can also be achieved [31] deserves to be explored more precisely.
Since this enzyme is overexpressed in brains from AD patients its selective modulation by non-covalent inhibitors becomes an interesting strategy in the search of potential drugs against this neuropathology.
Modulation of pH-driven conformational transitions by selective manipulation of the electrostatic component of the switch is an extremely difficult undertaking.
In the thalamus, astrocytically released GABA appears to target δ-subunit-containing extrasynaptic GABAA receptors, rather than γ2-subunit-containing synaptic receptors, as SOCs were insensitive to β-CCB, a benzodiazepine site, i.e. γ2-subunit-specific, inverse agonist, but were sensitive to modulation by the δ-subunit-selective agonist THIP, and were less frequent in mice lacking the δ-subunit.
Modulation doped GaAs/AlGaAs core shell nanowires were grown by selective area metal organic vapor phase epitaxy (MOVPE) on GaAs (1 1 1) substrates.
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