Sentence examples for modulation by small from inspiring English sources
It appears that all three major classes of G protein-coupled receptors (A, B and C) are amenable to allosteric modulation by small molecules.
Another strategy to target DAXX is by inhibiting its expression at the transcriptional level which can be attempted by performing high-throughput gene expression modulation by small molecules (GEMS) screening of compounds28,63.
Three phase discrimination methods between bubbles and tracer particles were introduced and compared in order to understand the turbulence modulation by small bubbles as accurately as possible.
In this Opinion article, we point out the importance of coupled binding and folding for protein protein signalling interactions generally, and from this and associated observations, we develop a new strategy for identifying protein protein interactions that would be particularly promising targets for modulation by small molecules.
Taken together with their modulation by small lipophilic molecules, they also represent an important and successful class of drug targets.
Several reviews of PPI modulation by small molecules have been published.
Using PTC's proprietary drug discovery platform technology referred to as GEMSAS (Gene Expression Modulation by Small-molecules – Alternative Splicing™) we have designed and conducted a high throughput screen of our compound library.
Hence, specific and potent modulation of PPIs by small, drug-like molecules would tremendously enlarge the "druggable genome" enabling novel ways of drug discovery for essentially every human disease.
Furthermore, the role of the cytoskeleton in the modulation of ENaC by small G proteins has never been investigated.
Alda-1 therefore represents as a new pharmacological agonist and opens the possibility that modulation of ALDH2 by small molecule enzyme activators should have therapeutic value for cardiovascular and other ALDH2-related diseases.
Recent progress in identifying small molecules targeting binding surfaces and interfaces of CRLs, such as SCFCdc4, ECSVHL, and SCFSkp2, suggests that other E3 ligases, including the ASB CRL family, may be also amenable to modulation by drug-like small molecules.
