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Strikingly, the metabolic genes detected in our study, particularly those related to nucleotide and amino acid metabolism, are upregulated after overexpression of MnSOD in Drosophila mitochondria, which extends the lifespan in Drosophila by decreasing the effect of oxidative stress in mitochondria and by modulating a variety of metabolic pathways through retrograde signaling of nuclear genes [50].

Cyclic di-nucleotides (c-di-NMPs) act as intracellular second messengers in bacteria, modulating a variety of cellular activities.

This suggests that bilateral movement training has a beneficial influence on motor performance by modulating a variety of intraspinal systems.

Cyclic dinucleotides act as intracellular second messengers, modulating a variety of cellular activities including innate immune activation.

Post-transcriptional regulation by small RNAs (sRNAs) in bacteria is now recognized as a wide-spread regulatory mechanism modulating a variety of physiological responses including virulence.

Matricellular proteins have been classified as a family of non-structural matrix proteins capable of modulating a variety of biological processes within the extracellular matrix (ECM).

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Taurine modulates a variety of cellular functions, including antioxidation, modulation of ion movement, osmoregulation, modulation of neurotransmitters and conjugation of bile acids etc. (Huxtable 1992; Satoh 1998; Schaffer et al. 2000; Sjovall 1959).

It is well documented that celastrol can modulate a variety of signaling pathways.

These processes modulate a variety of mitochondrial functions, allowing living cells to respond properly to frequently changing environmental conditions.

Although low levels of ROS modulate a variety of cellular functions such as cell proliferation, high concentrations of ROS cause cell damage or apoptosis (Park et al. 2008).

Polymer nanofiber scaffolds can be designed in a way that predictably modulates a variety of important cell behaviors towards a desired overall function.

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