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These studies provide proof-of-concept evidence that mGlu7 activity can be modulated by positive allosteric modulation, paving the way for future therapeutics development.
Cell growth is modulated by positive and negative signals, and loss of negative growth constraints may contribute to oncogenic processes.
The HER signaling system has been described as a complex, robust, and redundant biological network, modulated by positive and negative feedback circuits [ 2].
It is known that initiation of lateral roots modulated by positive and negative feedback regulation between tasiRNA-ARF and ARF2/3/4 through auxin signaling [ 38, 39].
Poor insight is a core attribute of schizophrenia, occurring in 57 98 % of patients [ 9, 10] and it is modulated by positive symptom severity [ 11].
We hypothesized that the COS-related local dV/dP change reflects intratidal nonlinear lung mechanics modulated by positive end-expiratory pressure (PEEP).
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When presented with face stimuli, the N170 component was mainly modulated by valence (positive > negative) and showed independence from compatibility effects.
Cell cycle progression and transitions in mammalian cells are regulated by a subfamily of CDKs, the activity of which is modulated by several positive regulators (cyclins) and negative regulators (inhibitors).
Like many other central response pathways, oxidative stress is modulated by a myriad of positive and negative signals that are transduced primarily via the levels of NRF2 in the nucleus.
The analyses of the parameter p show that: 1) The frequency of waves can be modulated by the strength of positive feedback and 2) the dependence is non-monotonic, i.e. the frequency is maximal (corresponding to period of 4.5 hours) at intermediate values of p and 3) there exists a "locked" state with high T concentration and infinite refractory period - see Figure 4D.
P3 amplitudes also showed no specific effect for the spider phobic group, but the amount of positive deflection was modulated by the ambiguousness of pictures, following a quadratic parabola with largest positive deflections for the most ambiguous and smallest for the unequivocal anchor pictures in the stimulus dependent analysis.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com