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Hepcidin is the main regulator of systemic iron homeostasis and its expression is modulated by iron status, hypoxia, erythroid factors and inflammation.
This hormone is modulated by iron homeostasis, hypoxia, erythropoiesis and inflammatory stimuli [ 17, 18].
In addition, we tested whether NF-κB activity could be modulated by iron levels.
The pathogenesis of T. vaginalis is a multifactorial process and its virulence is differentially modulated by iron [ 51].
In addition to heme-mediated feedback inhibition of enzymatic function, ALAS-2, a member of a small family of genes is modulated by iron [ 38].
The transcription profile of genes whose expression is modulated by iron levels was mapped by a DNA microarray analysis, and revealed 155 genes which were iron-regulated; one third of these were regulated by IdeR [ 94].
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In concordance with this dual function, its expression is modulated by systemic iron requirements and inflammatory stimuli, as it is induced by cytokines such as IL-6 [ 3].
These data suggest that TvLEGU-1 could have multiple functions that will depend on its cellular localization possible modulated by the iron concentrations.
It is also something that deserves further investigation to help to understand the way this protein is processed, activated, localized, and showed different functions that could be modulated by the iron concentrations in the microenvironment.
Hepcidin expression is modulated by systemic stimuli such as iron stores, hypoxia, oxidative stress and inflammation [ 31, 41].
The data are modulated by 16QAM modulation.
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adjusted by iron
regulated by iron
altered by iron
modified by iron
modulated by par
modulated by metal
adapted by iron
modulated by change
modulated by phonology
modulated by emotion
modulated by respiration
modulated by performance
modulated by dopamine
modulated by degree
modulated by color
modulated by cell
modulated by doping
modulated by task
modulated by block
modulated by hypothermia
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