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These results also suggest independently that inhibition of angiogenesis may represent part of the mechanism by which semaphorins modulate tumor progression, but that it may not always be sufficient to inhibit tumor growth.
These results show that changes in the stromal cells secondary to host hypothyroidism can modulate tumor progression and metastatic growth independently of the presence of TRs on the tumor cells.
Recent molecular studies have identified multiple factors that modulate tumor progression, invasion, and metastasis formation.
The immune cells in tumor microenvironment have been found to modulate tumor progression [ 29].
It has been widely accepted that tumor cells and normal stromal cells in the host environment coordinately modulate tumor progression.
DNA methylation alterations are potential markers for DCIS outcome prediction and may identify cellular changes that modulate tumor progression.
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We investigated the role of the hematopoietic cytokine erythropoietin as an angiogenic factor that modulates tumor progression.
HSPGs are key players in modulating tumor progression processes including metastasis, angiogenesis, proliferation, and malignant transformation [ 4].
Both in vitro studies and animal models have demonstrated the importance of interactions with the microenvironment in modulating tumor progression [ 2].
Together with clinical and experimental findings, we propose CARD9 as a new target for cancer therapy, and further studies of the mechanisms regulating metastasis-associated macrophages could provide novel insights into understanding how the tumor microenvironment modulates tumor progression.
However, further experiments will be required to confirm the role of SIPA1 germline variation in modulating tumor progression efficiency, the most obvious of which is to replicate the associations seen here in other populations.
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