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Within this octameric complex, SUR can modulate the gating of Kir6.2 under the influence of internal adenine nucleotides and pharmacological compounds such as sulfonylureas and K-channel-openers[7], [8].
Moreover, because the dimerization of ATDs may be an important initial step along the tetrameric assembly pathway of the NMDA receptor [16] and because the ATDs modulate the gating activity of the receptor [17], [18], probing the precise mode of ATD association will help in understanding the principles of NMDA receptor assembly and gating.
Moreover, intracellular pH can also modulate the gating of gap junction channels.
Xu et al. found that actin could modulate the gating of VDAC in Neurospora crassa [ 43].
Due to the C-terminal tail of LTCC having a high probability to be nitrosylated or oxidized, NO and ROS can modulate the gating properties of LTCC.
RyRs are ion channels in the endoplasmic reticulum (ER) that regulate Ca2+ release from the ER and modulate the gating response and signal gain of plasma membrane ion channels, including the NMDA receptor (Pessah et al. 2010).
Similar(53)
One LED was mounted on top of the gate electrode, acting as a photon sensor to modulate the gate voltage of TFT.
A class of these peptides acts by modulating the gating mechanism of voltage-gated ion channels and are thus called gating modifier toxins (GMTs).
In order to elucidate the mechanisms for the drug-mediated enhancement of Ih, we first examined whether SKF83959 modulates the gating mechanisms of Ih channels.
KCNE1 significantly modulates the gating, permeation, and pharmacology of KCNQ1 (Wrobel et al., 2012; Sun et al., 2012; Abbott, 2014).
The above results indicate that the decreased nNOS activity combined with the elevated ROS in cardiomyocytes of SUS rats reduces the responsiveness of LTCC to ISO through modulating the gating properties of LTCC.
Related(20)
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